Pimafucin suppositories instructions for use for women. Pimafucin - instructions for use. International nonproprietary name

Almost every woman of one age or another experiences symptoms of candidiasis. The standard treatment regimen for this infection suggests using Pimafucin suppositories for thrush, which have many positive reviews from different segments of the population.

Vaginal suppositories Pimafucin are made on the basis of natamycin and a number of auxiliary components:

• polysorbate;
• adipic acid;
• sodium bicarbonate;
• cetyl alcohol;
• sorbitan trioleate;
• hard fat.

The composition of each suppository includes 100 mg of natamycin.

When fighting against thrush, Pimafucin suppositories exhibit a strong antifungal effect. Natamycin promotes the destruction of bonds in the cells of bacterial bodies, and therefore the latter lose their activity.

The drug counteracts most pathogenic fungi. It is especially active against pests of the genus Candida, which cause thrush.

Significant resistance to the drug is demonstrated by dermatophytes that affect the skin of the feet, nails, and folds between the toes.

Resistance to the active substance natamycin has not yet been observed.

Pimafucin suppositories: instructions for use

Pimafucin suppositories for candidiasis in women are used intravaginally. The shape of the suppositories allows you to easily insert the medicine into the vagina. For this purpose, you can use a polyethylene fingertip. After inserting the suppository, it is necessary to spend some time in horizontal position.

Dissolving under the influence of elevated body temperature, the product takes on a foamy consistency that ensures coverage of all corners of the affected mucous membrane for better disinfection. When liquefied, the remains of the suppository may leak out of the vagina. To protect the laundry you need to use pads.

Pimafucin does not have a systemic effect on the body.

The gynecologist will answer the question of how many suppositories the course of treatment includes. The standard regimen involves administering one unit of medication inside the vagina once a day, preferably at night.

The course can last for three or six days, depending on how the disease progresses. For how many days to use Pimafucin, you need to consult a gynecologist.

If vaginitis is advanced, it is recommended to take a tablet form (one tablet is taken at regular intervals four times a day for 2-3 weeks).

According to the instructions, there is no need to interrupt sexual activity while using the medicine. You just need to use barrier contraceptives (for example, condoms).

The use of the drug should be stopped and resumed after bleeding has stopped. It is better to plan the course of therapy in such a way that it is not interrupted. Then the medicinal effect of treatment will appear faster.

Cases of overdose have not yet been registered. In medical practice, there is no mention of the interaction of the active substance natamycin with other drugs.

The use of Pimafucin does not affect the ability to drive a car or other complex mechanisms.

Description

The suppository is made in the form of a torpedo and has a yellowish-white or brownish-yellow color. Candles are packed in contour cells made of aluminum foil, three pieces each. A cardboard box contains 3 or 6 units of medicine.

The shelf life of the product is 24 months. Pimafucin should be stored at an air temperature of no more than +25ºC. Admission to the drug to children is prohibited.

Who are they shown to?

The product exhibits a local antifungal effect. Instructions for the use of Pimafucin suppositories for thrush contain a list of diseases during the treatment of which they are used. The medicine helps in the fight against vaginitis, vulvitis, vulvovaginitis, provoked by yeast-like fungi, including pathogens of the genus Candida.

Suppositories are also indicated for the prevention of thrush.

Contraindications and side effects

Pimafucin is contraindicated for use by persons who have hypersensitivity to the components of the drug.

At the beginning of the course of treatment, the digestive system may experience some upset, nausea and diarrhea are possible. Side effects caused by taking the tablet form. After a few days, these symptoms should stop.

Vaginal suppositories cause mild irritation or irritation in some patients. This kind of reaction is explained by the presence of cetyl alcohol in the composition and its interaction with the vaginal mucosa.

How to use Pimafucin suppositories against thrush?

For successful treatment of thrush, you need to follow the recommendations of the gynecologist. Self-medication should not be practiced under any circumstances.

Typically, the course of Pimafucin is 3-6 days. In some cases, complete healing may take up to 10 days.

One suppository is inserted into the vagina every day. It's better to do this before bed. If candidiasis occurs in an acute or particularly severe form, the doctor may prescribe the drug twice a day.

After disappearance, you can continue treatment for 2-3 days in order to prevent relapses.

Is it possible during pregnancy?

Candidiasis develops against the background of a decrease in the body's protective properties. Decreased immunity is also typical for. Therefore, thrush is a common occurrence during pregnancy. Gynecologists consider it a completely safe method of treating the disease to use Pimafucin suppositories for thrush during pregnancy.

The drug will not harm either the pregnant woman herself or her pregnant child.

Usually during this period the drug is prescribed in the form of vaginal suppositories.

Where can I buy?

Pimafucin suppositories can be purchased in pharmacies and drug stores throughout the country.

The drug can be ordered online for delivery or pickup. The catalog immediately indicates how much Pimafucin suppositories for thrush cost. When ordering from online pharmacies, the cost of the medicine may be lower than in the retail network. In addition, it is more convenient to keep track of current promotions and discounts online.

How much do Pimafucin suppositories cost for thrush?

The price of suppositories for thrush Pimafucin may be different in different pharmacies. A package of 3 suppositories costs between 270 and 320 rubles. Six candles in a package will cost from 460 to 530 rubles.

To find out where to buy candles cheaper, you can first look online.

Pimafucin suppositories are an antifungal agent designed to combat diseases of the female genital area caused by yeast-like fungi. The drug is particularly effective against fungi of the genus Candida, so it is often prescribed in the treatment of thrush. Pimafucin is produced in different dosage forms (tablets, suppositories, cream). For the treatment of candidiasis in gynecology, suppositories are used, since this form is more convenient to use and allows you to quickly cope with the main symptoms of the disease.

Pimafucin suppositories are a powerful antifungal drug with a wide spectrum of antibacterial action. It is based on the macrolide antibiotic natamycin, from the polyene group. The active substance has a powerful fungicidal effect by binding sterols in the cell membrane of the fungus. As a result, the growth and reproduction of the fungal cell is blocked, its structure is destroyed, which leads to the death of the microorganism.

Most strains of yeast fungi are sensitive to natamycin, but the drug is particularly active against fungi of the genus Candida. Dermatophytes are much less sensitive to natamycin. However, in medical practice there have been no cases of microorganisms developing immunity to the active substance of Pimafucin.

When administered vaginally, the suppositories quickly melt and acquire a foamy consistency, due to which the active component is evenly distributed inside the vagina. When interacting with mucous membranes, natamycin is practically not absorbed and does not penetrate into the bloodstream, therefore it does not provoke systemic reactions and does not cause side effects.

Yeast-like fungi live in the intestines, mucous membranes of the mouth and genitals. If the body's defenses are in order, they are absolutely harmless, since the immune system reliably suppresses their growth and reproduction. But as soon as the immune system fails (for example, during pregnancy or as a result of exacerbation of chronic diseases and colds), pathogenic microflora begins to multiply rapidly and provokes symptoms of candidiasis.

Vaginal candidiasis (or thrush) in women manifests itself in a feeling of itching, burning in the genital area and is accompanied by the appearance of white, curdled discharge. Often these symptoms are complicated by the appearance of an unpleasant odor, pain during sexual intercourse, and discomfort when urinating. The mucous membranes of the genital organs become hyperemic, swollen, and painful erosions and ulcers may appear on them.

If timely treatment is not started, the disease can lead to such unpleasant consequences as cervical erosion and disorders associated with pregnancy. If a woman notices in herself characteristic symptoms, you should immediately seek advice from a gynecologist. After the examination, the doctor will select the necessary treatment regimen, which will most likely include Pimafucin suppositories for thrush. (Meet another one)

Pimafucin vaginal suppositories are torpedo-shaped and white in color, with a slightly yellowish tint. 1 suppository contains 100 mg of natamycin + auxiliary components (solid fat, polysorbate, sodium bicarbonate, cetyl alcohol, etc.).

Candles of 3 pieces are packaged in foil strips and placed in cardboard boxes. One pack may contain 1 or 2 strips of candles.

Pimafucin vaginal suppositories are used to treat genital diseases in women caused by Candida fungi. Indications for prescribing the drug are the following conditions:

• Thrush (vaginal candidiasis);
• Vaginitis;
• Vulvitis;
• Vulvovaginitis.

Pimafucin suppositories can be used to prevent recurrence of thrush and other fungal infections of the vagina that develop when immunity is reduced as a result of long-term use of antibiotics.

Exacerbation of thrush often occurs during pregnancy, since it is at this time that a woman’s hormonal background rapidly changes, and the body’s defenses weaken. During intrauterine development, the unborn baby is not in danger, but when passing through the birth canal, the child can be initiated pathogenic microflora. Therefore, if symptoms of thrush are detected during pregnancy, the fungal infection should be treated immediately.

Many women are interested in whether it is possible to use Pimafucin suppositories during pregnancy? Experts believe that this is a completely harmless drug, since its active substance does not penetrate the systemic bloodstream and cannot have a negative effect on the development of the fetus. Therefore, Pimafucin suppositories are one of the few antifungal drugs approved for use not only during pregnancy, but also during lactation (breastfeeding).

Instructions for use of Pimafucin suppositories prescribe the use of 1 suppository per day. The suppositories are removed from the packaging and inserted into the vagina as deeply as possible, in a lying position. The procedure is recommended to be done before bedtime. The course of treatment ranges from 3 to 6 days, its duration is determined by the doctor individually and depends on the severity of the symptoms and the general condition of the patient. Suppositories do not require preliminary wetting; when interacting with the mucous membrane, they quickly dissolve and form a foamy substance that envelops the walls of the vagina.

If vaginitis and other infections caused by Candida fungi persist, the doctor may additionally prescribe Pimafucin tablets. At the same time as the woman, her partner should also be treated. For men, to treat the genitals for candidiasis, Pimafucin is prescribed in the form of a cream.

Contraindications

An antifungal agent in the form of suppositories, unlike other antimycotic drugs, is safe and well tolerated. The only contraindication to the use of Pimafucin suppositories is individual intolerance to the active substance - natamycin, or the auxiliary components in the drug.

Pimafucin suppositories have no restrictions for use during pregnancy and lactation, since the active substance does not penetrate the systemic bloodstream. Many young girls are interested in whether it is possible to use Pimafucin suppositories during menstruation? Instructions for use of Pimafucin suppositories warn that suppository therapy should be interrupted during menstruation. This is due to the fact that the drug will be washed off with menstrual blood and will not have the desired therapeutic effect.

Pimafucin suppositories are well tolerated by patients. But in some cases, the use of the drug can provoke a feeling of itching, burning, redness and slight swelling of the genitals.

All these phenomena are temporary and quickly pass with further use of the candles. In the case when a woman takes Pimafucin tablets at the same time as suppositories, nausea and loose stools may occur. These symptoms also disappear without a trace after discontinuation of the drug.

If the fungal infection becomes chronic and manifests itself with constant relapses, treatment with suppositories is supplemented by taking Pimafucin tablets and cream for external use.

Vaginal suppositories contain cetyl alcohol; it can cause irritation reactions in patients who are hypersensitive to this component.

During treatment with the drug, you should avoid drinking alcohol, as this can lead to unpredictable consequences. Alcoholic drinks can provoke an exacerbation of fungal infection (especially with intestinal candidiasis) and significantly reduce the effectiveness of antifungal therapy.

While using suppositories there is no need to avoid sexual intercourse. However, experts recommend that the woman’s partner also undergo an examination in order to exclude the presence of an infection or, if a candidal lesion is detected, prescribe the necessary treatment regimen. Additionally, barrier contraception should be used during therapy.

How much do Pimafucin suppositories cost - average prices

Pimafucin vaginal suppositories can be purchased freely in pharmacies without a doctor’s prescription. The cost of the drug is quite high and it depends on the manufacturer, the number of suppositories in the package and the sales markup of pharmacists. Here are the average prices for the drug:

• Pimafucin suppositories 3 pcs. price – from 260 rubles;
• Pimafucin suppositories 6 pcs. price - from 550 rubles.

Since the drug is quite expensive, many patients are interested in cheaper analogues of the drug. If necessary, the doctor can choose a more affordable drug.

You should not replace the medication yourself, since another antifungal agent has its own contraindications and its use may provoke unwanted side reactions.

Analogues

Structural analogues of Pimafucin suppositories in terms of the active substance are suppositories Natamycin and Primafungin. Both drugs contain the active substance natamycin and have an identical therapeutic effect. These analogues have the same principle of action and effectively destroy pathogenic microflora. The drugs are completely safe and can be used during pregnancy and breastfeeding. There are practically no side effects. There is only one contraindication, like Pimafucin, – individual intolerance to the components.

In addition, drugs such as Clotrimazole, Nystatin, Livarol are used as a cheaper option. Livarol suppositories are considered one of the best analogues with a similar therapeutic effect. The active ingredient of the drug - ketoconazole - copes well with various strains of yeast-like fungi and dermatophytes.

But unlike Pimafucin, this drug cannot be used in the 1st trimester of pregnancy, and there is a risk of developing adverse reactions higher when using Livarol. This drug costs from 360 rubles, but the package contains 5 candles. Nystatin suppositories are the cheapest, their price is 85-90 rubles.

Clinical studies of the antifungal drug Pimafucin included women with various types vaginitis and other fungal infections of the genital area. The effectiveness of the drug according to the test results was confirmed in all cases, and the best results were obtained in the treatment of infections caused by Candida fungi.

The study, conducted at the Moscow Center for Obstetrics and Gynecology, involved 32 women in the first trimester of pregnancy. All patients had symptoms of candidal vaginitis.

During the treatment, they received 1 suppository of Pimafucin before bedtime and in parallel took 1 tablet of Pimafucin four times a day. Already on the second day of treatment, almost all patients (30 people) noted the disappearance of unpleasant symptoms and improvement in well-being.

Upon completion of the course of treatment, all women noted the disappearance of the main manifestations of infection: itching, irritation, vaginal discharge. Microbiological studies carried out at the end of therapy confirmed the absence of fungal cells and spores and indicated complete recovery.

In the remaining two patients, the unsatisfactory treatment result is explained by chronic vaginitis and repeated attempts at self-medication with a variety of antifungal agents.

Such unsystematic therapy led to the fact that pathogenic microorganisms developed resistance to traditional drugs, and the effectiveness of the active ingredient Pimafucin decreased. Therefore, experts never tire of repeating that self-medication is dangerous. This can lead to unwanted complications and make subsequent treatment of the infection more difficult.

In general, reviews of Pimafucin suppositories are positive. Women note the ease of use, high efficiency and safety of the antifungal agent and say that with its help they can quickly cope with unpleasant symptoms and defeat the disease.

Another undoubted advantage is the ability to use Pimafucin suppositories during pregnancy and lactation, since the drug does not have a negative effect on the health of the mother and child. These advantages of the drug make it especially popular and in demand. Pimafucin has helped many women get rid of problems associated with genital candidiasis.

Price in online pharmacy website: from 256

Statistics, facts, theory

Pimafucin (trade mark) is an antibacterial drug active against fungal microflora. Effective against many fungal diseases of the skin, genitals, nails and other tissues.

The drug is produced by the Italian pharmaceutical company Temmler Italia, which has its headquarters in Russia. The company produces and markets hydrocortisone cream for external use, hydrocortisone ointment, as well as emulsions and other dosage forms for the treatment of fungal pathologies.

Dermatomycosis is a large group of skin lesions, the etiological factor of which is mold fungi. You can become infected with a fungal infection through household contact with a carrier, as well as with objects that have spores on them. Some diseases are caused by opportunistic microflora and appear only when the body's immune defense is weakened. Keratomycosis is a disease caused by fungi, in which the lesion is located in the stratum corneum. Skin appendages, hair, and nails are not affected. Infectiousness is very low. This group includes diseases such as lichen versicolor, erythrasma, and actinomycosis. Lichen versicolor is a fairly common pathology. Clinically manifested by the presence of pink to brown spots with superficial peeling in the form of bran. Typical locations: neck, chest, upper back, shoulders. There are no inflammatory reactions on the skin. Most often, teenagers and people under forty get sick. Increased sweating can be considered a risk factor. The rashes may coalesce to form large spots different shapes with scalloped edges. Exacerbations are typical for the spring period. Differential diagnosis is carried out based on the patient’s complaints, medical history, instrumental and laboratory research methods. A specific test is a scraping examination, a test with iodine. Treatment is prescribed in a comprehensive manner with etiotropic, pathogenetic and symptomatic components.

Actinomycosis is a skin disease caused by actinomycetes that takes a chronic course with exacerbations and remissions. The risk group is workers of mill farms, agricultural enterprises, bakeries, and places where actinomycetes live. If spores of an infectious agent enter the digestive tract, the intestinal tube may be damaged. In the lesion on the skin, an infiltrate of dense consistency is formed, which increases the area of ​​the lesion over time. Diagnosis is carried out by questioning the patient for complaints. Life history and profession are important. In addition, microscopy of the scraping is carried out, and if necessary, bacteriological examination. Treatment also includes all types of drugs aimed at both the cause of the disease, the symptoms, and the vicious circle of pathogenesis. In advanced situations, even surgical treatment by excision of tissue is indicated. To prevent actinomycosis, it is necessary to maintain personal hygiene, use individual caps, hats, personal hygiene items, combs, washcloths, and wash your hands after contact with animals.

Dermatophytosis is a chronic skin disease caused by fungi. The superficial epidermis is affected, inflammation with hyperemia, swelling, local fever, pain and dysfunction is observed. Trichophytosis is caused by an anthropophilic fungus and is characterized by superficial skin lesions. You can become infected from a sick person, animal or environment. The lesion is a round formation on the part of the head where the hair grows. Accompanied by fragility and pathological hair loss, exfoliation of the epidermis. Women under forty are more often affected. Risk factors include a lack of vitamins in the body and endocrine pathologies. Microsporia is clinically very similar to the previous disease. To confirm the diagnosis, microscopy of the scraping is performed; in the case of microsporia, mycelium can be detected, but to differentiate from trichophytosis, a cultural study is necessary. Favus affects the scalp, nail plates, and very rarely internal organs when it enters the digestive tract. Characteristic is the presence of a scutula - a cortical lesion with depression and hyperemic skin around it. The smell of scutula is unpleasant, fungal. Hair breaks, falls out, and takes on an unhealthy appearance. Treatment with antibacterial drugs is prescribed for a week, and ointments are used for topical application.

Rubromycosis of the feet is a lesion of the skin of the feet with characteristic mucoid peeling and dryness. Accompanied by pain and itching. Diagnosis is carried out taking into account the patient’s complaints, medical history, clinical picture, as well as laboratory and instrumental research methods. Most effective method– cultural. Therapy depends on the severity of the lesion and the pathogen. Usually a fairly long course of antifungal drugs is prescribed. Additionally, laser treatment may be needed. For prevention, it is necessary to maintain personal hygiene, wash your feet after visiting public places, saunas, baths, swimming pools, beaches. Wearing socks made from natural fabrics is recommended to prevent excessive sweating of the feet.

Candidiasis is a disease of the skin, mucous membranes and internal organs caused by yeast-like fungi of the genus Candida. The fungus is opportunistic, the disease occurs when activity decreases immune system person. There is a risk group: children, old people, people with immunodeficiencies. The corners of the mouth (jams) may be affected with maceration and plaque, which, when removed, reveals an eroded surface. On the skin, the process usually develops in obese people, those who are prone to hyperhidrosis. The lesion has a bright red tint, clear boundaries, plaque on the surface, and detachment of the epidermal layer at the periphery. During treatment, a special diet is prescribed with a restriction of sweets, butter, flour, simple carbohydrates. In addition, etiotropic, pathogenetic and symptomatic treatment is effective, as well as therapy for dysbiosis, restoration of normal microflora after a course of antibiotics, and normalization of the body’s immune system.

Pharmacological group

Pimafucin is an antimycotic drug that is effective against fungal infections of the skin, mucous membranes and rare forms of damage to internal organs. It is used both in outpatient settings and at the hospital stage during hospitalization.

Release form and component composition of Pimafucin

There are three dosage forms of the antimycotic:

• Film-coated tablets for passage through the stomach. The total number of tablets in the package is twenty pieces.
• Suppositories for vaginal administration, effective against fungal infections of the genitals. Packaged in plastic cases. The total number of suppositories is three or six pieces, depending on the package purchased.
• Two percent cream for application to lesions on the skin and mucous membranes. Available in tubes weighing thirty grams.

The box with the drug contains instructions for use, which describe all the rules for using dosage forms.

Pimafucin tablets contain an active substance - the antifungal component natamycin in an amount of one hundred milligrams. In addition, there are a large number of excipients and tablet shell components. Suppositories for insertion into the vagina also contain one hundred milligrams of natamycin and a large number of additional substances. One gram of cream for external use contains twenty milligrams of active pharmaceutical substance and auxiliary components for giving the dosage form.

Pharmacological action and pharmacokinetic parameters of the antimycotic agent

Natamycin is an antibiotic of the antifungal group. It has a fairly wide range of effects. It binds to components of the fungal cell membrane, disrupts permeability, which ultimately leads to cell death. Active against candida, trichophytes, microsporum, epidermophytes, aspergillus and other fungi. The systemic effect is insignificant, which reduces the risk of side effects. It is absorbed in small quantities both from the intestines when taking tablets and transdermally when applying the cream externally. When using suppositories for vaginal administration, foam is formed, which helps distribute the main pharmaceutical substance evenly.

Range of indications for the use of Pimafucin

An antifungal drug is effective in the treatment of diseases and pathological conditions such as:

• Damage to the skin and mucous membranes by a fungus to which Pimafucin is sensitive.
• Thrush, or acute pseudomembranous candidiasis.
• Intestinal candidiasis (for tablet dosage form).
• Inflammation of the vagina, vulva, caused by fungi, to which natamycin is sensitive (for vaginal suppositories).
• Acute atrophic candidiasis.
• Fungal infection of the ear, skin, nail plates, scalp.

Range of contraindications to the use of the antimicrobial agent Pimafucin

Do not use the medicine if you have a history of allergic reactions to antifungal drugs. In this case, it is necessary to check the body’s sensitivity to taking the drug, and only then – its full use for treatment and prevention.

Side effects after using the drug

Possible undesirable effects such as:

• Allergic responses of the body to taking, applying or administering a medication in the form of rash, itching.
• In the first days of the course of therapy: symptoms of nausea and vomiting, pain in the intestines or stomach, usually passing quickly and not requiring the use of painkillers and antiemetics.
• Local reactions at the site of application of the cream: swelling, itching, hyperemia, mild irritation.
• Local reactions after administration of suppositories: irritation, burning, itching, pain.

If undesirable reactions occur, you should contact your doctor for clarification and to decide on the further use of the antifungal medication.

Use of cream, suppositories and tablets Pimafucin: method, features, dose

The tablets are taken orally, without chewing and with plenty of water, for the treatment of candidiasis of the intestinal tube. Adults take one tablet four times a day. Children – one tablet twice a day. The course of therapy is a week. Suppositories are inserted into the vagina with clean hands, opening the packaging of the suppositories immediately before use. The most convenient way for administration is in a lying position. Candles are used once a day at night. If the result is not achieved, an additional dose of the tablet dosage form is prescribed, since there may be a source of infection in the intestines. If the external genital organs are affected by candida, apply a cream. The duration of the course of therapy is determined at an appointment with a gynecologist. The cream is applied externally to the lesions one or several times a day. If the external auditory canal is affected by a fungus, apply cream to the area up to four times a day. A cotton swab is then placed in the ear.

Special points when using the product

It should be used with caution by persons who have a congenital deficiency of enzymes for the absorption of galactose, fructose, glucose-galactose malabsorption, or sucrase-isomaltase deficiency. Infancy is a contraindication for taking all dosage forms. Does not affect the ability to drive vehicles or perform activities that require high attention and concentration.

Use of the drug Pimafucin during pregnancy and before stopping breastfeeding

If a woman has indications, then use during pregnancy and lactation is possible. There is no risk to pregnancy or fetus.

Simultaneous use of the medication with other medications and compatibility with alcohol-containing drinks

Interactions with other drugs have not been described in the sources. It can be assumed that the use of the drug is not recommended to be combined with other antifungal agents in order to avoid an excessively pronounced effect on the body, since it is possible to inhibit the normal intestinal microflora.

Storage at home

Pimafucin at home - storage rules:

• The ambient temperature should not exceed twenty-five degrees, a dry place, protected from direct sunlight and moisture.
• The period during which you need to use the tablets and cream is four years. For vaginal suppositories, the shelf life is two years.
• It is necessary to store the drug in a place where children will not find it.

Purchasing a product

If necessary, according to a doctor’s prescription, the drug can be purchased at a pharmacy chain.

Analogues

There is a large selection of drugs with a similar mechanism of action: Primafungin, Griseofulvin, Nystatin ointment and others.

Excipients: cetyl alcohol - 690 mg, solid fat - 700 mg, sorbitan trioleate - 460 mg, polysorbate 80 - 460 mg, - 69 mg, adipic acid - 64 mg.

3 pcs. - aluminum foil strips (1) - cardboard packs.
3 pcs. - aluminum foil strips (2) - cardboard packs.

pharmachologic effect

Antifungal polyene antibiotic of the macrolide group, has a wide spectrum of antifungal action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms. To natamycin sensitive most pathogenic yeasts, especially Candida albicans.

Less sensitive dermatophytes to natamycin.

Resistance to natamycin has not been observed in clinical practice.

Pharmacokinetics

When taken orally, natamycin is practically not absorbed from the gastrointestinal tract. When applied to intact skin and mucous membranes, it is practically not subject to systemic absorption.

Indications

For oral administration: treatment and prevention of non-invasive bowel disease (including after taking antibiotics, cytostatics, corticosteroids).

For external and local use: infections of the skin and mucous membranes caused by Candida or other sensitive yeasts, yeast-like fungi or dermatophytes (including balanoposthitis, otomycosis).

For intravaginal use: vulvovaginal candidiasis.

Contraindications

Hypersensitivity to natamycin.

Dosage

When taken orally, a single dose is 100 mg. The frequency of administration for adults is 4 times a day, for children - 2 times a day.

Externally and locally applied 1 time or several times a day.

Intravaginally - 1 time/day at night for 3-6 days.

The duration of the course of treatment is determined individually. After the symptoms of the disease disappear, it is recommended to continue treatment for several more days.

Side effects

From the digestive system: Nausea is possible (occurs in the first days when taken orally and goes away on its own during treatment).

Local reactions: mild irritation and burning sensation are possible.

Content

In case of increased activity of fungi of the genus Candida albicans in the body, doctors recommend medicinal product Pimafucin. This medication has three dosage forms and is characterized by a local effect in the body. Self-medication is contraindicated.

Composition

The drug Pimufacin is a representative of the pharmacological group of antimycotic drugs. A medicine with fungicidal and antifungal properties is produced in the form of vaginal suppositories, tablets and cream. Features of each release form:

1. Round tablets white covered with an enteric coating. The medicine is packaged in glass bottles of 20 pieces. Instructions for use are included in the cardboard packaging.
2. Torpedo-shaped candles light yellow color intended for intravaginal use. The drug is packaged in aluminum foil scripts, 3 pcs. The cardboard package contains 2-3 scripts and an annotation.
3. A light cream-colored cream with a specific odor is intended for local use (externally). Spilled medicinal composition in aluminum tubes, 30 g each.

The characteristics of the chemical composition of Pimafucin depend on the form of release and are described in detail in the instructions. The active ingredient is the same, called natamycin. The concentration in tablets, suppositories and cream is different:

Pharmacodynamics and pharmacokinetics

Detailed instructions for the use of Pimufacin indicate that natamycin, being a polyene (tetraene) antibiotic of the macrolide group, binds to the walls of the pathogenic fungus, disrupts their integrity, and inhibits further growth and spread of pathogenic flora. Pimafucin is active against yeast and mold fungi. Positive dynamics are observed with activity:

• Candida;
• Aspergillus;
• Cephalosporium;
• Fusarium;
• Penicillium.

When using this medication against Pseudoallescheria boydii and dermatophytes, a mediocre therapeutic effect is observed, so it is better to immediately select an analogue. Pimafucin is absorbed in the lumen of the large intestine, the active substance penetrates into the bloodstream in relatively small doses. When applied locally, the drug has a mediocre effect on the site of pathology.

Indications for use

• cream: ringworm, diaper rash, vulvovaginitis, vulvitis, vaginitis, otitis, candidiasis of the nail plates and skin;
• tablets: candidiasis of the intestinal mucosa, long-term antibacterial therapy, taking cytostatics, corticosteroids, acute atrophic candidiasis, acute pseudomembranous candidiasis with cachexia;
• vaginal suppositories: thrush, vulvovaginal candidiasis, vulvovaginitis, vulvitis, balanoposthitis.

Directions for use and dosage

The drug Pimafucin effectively destroys pathogenic fungi of various localizations in the body. Recommended daily doses and method of administration of the drug depend on the form of release and the nature of the pathological process. Before starting the course, you must individually consult with your doctor.

Pimafucin suppositories

The drug Pimafucin for thrush is often recommended in the form of vaginal suppositories. The patient needs to insert 1 suppository into the vagina for 5–7 days without a break. In a complicated clinical case, the course of treatment is extended to 2–3 weeks. It is advisable to carry out the home procedure before going to bed, or after inserting the suppository, remain in a horizontal position for some time. Otherwise, the medicinal composition leaks out and the desired therapeutic effect weakens. Men are not prescribed suppositories.

Cream

This form of release of Pimafucin is equally suitable for women and men for the complex treatment of balanoposthitis, vulvovaginitis and vulvitis. The drug is intended for external use. According to the instructions, it is required to apply the medicinal composition to areas of pathology (skin, nails, genitals) up to 3-4 times a day. The course of treatment depends on the stage of the pathological process and is discussed individually.

Pimafucin tablets

For progressive intestinal candidiasis, doctors recommend taking Pimafucin tablets as a weekly course. During this time, an adult patient takes 4 tablets, a child - 2 tablets. per day. The recommended dose of the medicine must be swallowed whole, washed down with water. Do not pre-chew or dissolve in the mouth.

Pimafucin for men

When candidiasis worsens, doctors prescribe topical application of Pimafucin cream to men. In complicated clinical cases, an integrated approach to the health problem is recommended. Local application of the cream is supplemented with oral tablets. Daily doses and course of treatment with Pimafucin depend on the disease and are discussed individually with a specialist.

special instructions

Treatment of thrush with Pimafucin takes a full course, even if positive changes in well-being are noticeable after 2-3 days. If drug therapy is stopped prematurely, the disease will progress again. Instructions for use contain instructions for patients:

1. Pimafucin is prescribed with caution for glucose-galactose malabsorption and lactase deficiency.
2. For children infancy tablets are not prescribed because there are difficulties with their oral administration.
3. The drug does not inhibit functions nervous system, therefore, during treatment it is allowed to drive a vehicle and engage in intellectual activities.

During pregnancy

The medical drug Pimafucin is recommended for use by pregnant women. Treatment takes place under medical supervision with individual adjustment of the prescribed daily dosage. For chronic infections, oral tablets are often supplemented with local vaginal suppositories. The course of treatment lasts from 7 to 10 days. During lactation, such pharmaceutical prescription is also not prohibited. Doctors recommend temporarily stopping breast-feeding, transfer the child to adapted formulas.

Pimafucin for children

For candidiasis of the gastrointestinal tract, doctors do not prohibit the use of Pimafucin in childhood. According to the instructions for use, the recommended dosage is 1 tablet. in the morning and in the evening. In complicated clinical cases, the permissible dose is increased to 4 pcs. Additional use of suppositories and Pimafucin cream is discussed with the pediatrician.

Drug interactions

Tablets, cream and suppositories for thrush Pimafucin are recommended to the patient as part of a complex treatment to exterminate pathogenic fungal flora. In the detailed instructions for use, information about drug interactions with representatives of other pharmacological groups not provided. Doctors warn patients against self-medication.

Side effects

Pimafucin is well tolerated by the affected organism. Side effects occur extremely rarely, are presented in the instructions for use of the drug:

• digestive tract: nausea, vomiting, diarrhea;
• allergic reactions: skin rash, urticaria, swelling and hyperemia of the epidermis;
• local reactions when using suppositories and cream.

Contraindications

The drug Pimafucin is not approved for use by all patients. According to the instructions, the list of medical contraindications is limited to increased sensitivity of the body to the active ingredients of the specified antifungal agent. Age restrictions must be individually agreed upon with a dermatologist or local pediatrician.

Terms of sale and storage

Pimafucin is sold in pharmacies and is available without a prescription. According to the instructions for use, the medication must be stored in a dry and cool place, away from sunlight and inaccessible to small children. The shelf life of Pimafucin is 24 months.

Analogues

If Pimafucin does not help destroy pathogenic flora, doctors recommend replacing the antifungal drug. Reliable medicines with antimycotic and fungicidal effects, their brief characteristics:

1. Alpha Normix. These are round orange tablets containing rifaximin. chemical composition. According to the instructions, the patient is prescribed 1 tablet. every 8 hours. The course of treatment is no longer than 7 days, doses are adjusted individually.
2. Nystatin-Health. An antifungal agent in the form of film-coated tablets with nystatin in the chemical composition. According to the instructions, 1–2 tablets are prescribed. per day for 1–2 weeks without a break.
3. Nystatin. These are vaginal suppositories, ointments and capsules with the same active ingredient. According to the instructions, these release forms are allowed to be combined in one treatment regimen to enhance the therapeutic effect.
4. Livarol. These are vaginal suppositories, recommended for thrush, with ketoconazole in the chemical composition. According to the instructions for use, the medicine is approved during pregnancy and lactation. The patient is prescribed 1-2 soups. per day.
5. Terzhinan. This is an expensive drug with an antifungal effect in the form of vaginal suppositories. According to the instructions, the patient is prescribed 1 suppository before bedtime. After the dose is administered, it is recommended not to get out of bed.
6. Clotrimazole. This medication has five forms of release - gel, cream, ointment, solution, tablets, vaginal suppositories. Contains the same component of varying concentrations. Daily doses and course of treatment are described in the instructions for use.

Pimafucin price

The cost of this medication varies from 450 to 600 rubles. Purchasing online is cheaper for the patient. The retail price depends on the form of release of the medicine, the configuration of each package, and the rating of the capital's pharmacy.

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